[Results] 96 weeks, 40kg, and 2.4mg was the hard part
Six-word version is the title — 96 weeks, 40kg, and 2.4mg was the hard part — and the rest is context.
The relevant figures are 96 weeks, 40kg and 2.4mg, and they come from the same log I have kept the whole time.
Sat at 1.7mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the early fullness.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the sulphur burps usually fades at a stable dose.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Standard reminder: no personal titration plans for other members, and no medical advice. Everything else is fine.
Did protein intake change in the same window?
Week 83: 20kg down, constipation basically gone since about week 4, and the honest headline is that nothing dramatic happened. It was boring and it worked.
What did week 40 look like compared with this one? The month either side is the useful comparison.
Week 83: 20kg down, constipation basically gone since about week 4, and the honest headline is that nothing dramatic happened.
vikram_ferreira is describing the standard shape here and it matches the trial data better than most anecdotes do.
Standard reminder: no personal titration plans for other members, and no medical advice.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
the scale is the least sensitive instrument you own
the scale is the least sensitive instrument you own
This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.
sema is weekly for a reason, the half-life does the smoothing
What dose and how many weeks at it before this started?
nausea that arrives on day two and fades by day four is the standard shape
stalling at 0.25mg is information, not a verdict
nausea that arrives on day two and fades by day four is the standard shape
Disagree with this specific line. A pause at 0.5mg is not evidence that 0.5mg has stopped working.
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
nausea that arrives on day two and fades by day four is the standard shape
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Strongly agree on protein. It did more for my muscle cramps than any of the things I bought to fix my muscle cramps.
if 0.25mg is working there is no prize for going up
fatigue made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.
First month I lost almost nothing and nearly quit. Month two and three were where it all happened.
Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.
the first four weeks are a tolerance check, not a weight-loss phase
2.4 is a ceiling, not a target
the food noise going quiet is the effect people actually describe
week 39 plateau is the most predictable thing in this entire board
I would push back gently. Going up because the scale paused is the single most common mistake described on this board.
Same injection day each week, or has it drifted?
- 1The escalation schedule in the trials existed to keep people on the drug. It…11 comments in this branch · started by u/coa_janitor
- 2Standard reminder: no personal titration plans for other members, and no…9 comments in this branch · started by u/units_not_mg