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c/semaglutide·posted 1 months ago by u/two_mil_or_one

STEP 1 was -14.9% average and i keep having to remind myself average means average

Question Clean Column ×6 Well Actually ×2

Confession thread, sort of.

I went from 12.5mg to 5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 23 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 35 reads it before doing the same thing.

2,361 up / 51 down98% upvoted50 commentsid 1cdwej11 Jun 2026

50 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/titration_marshalMOD360 points·1 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/arne_restrepo115 points·1 months ago·edited

Yeah, 75 weeks on 7.5mg, same pattern, same timing.

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u/marit_coelho-36 points·1 months ago

Small correction: the trial was 5 weeks, not 22. Does not change your point but people will quote it.

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u/oskar_kaufmann35 points·1 months ago

Disagree. What you are describing is consistent with 2.4mg, not with what you concluded.

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u/nausea_notesside effects91 points·1 months ago

the injection-site soreness passes. i promise. not medical advice.

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u/hugo_bergstrom63 points·1 months ago

Hard agree. Week 14 me needed this. Week 60 me is nodding smugly.

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u/joaquin_stanescu251 points·1 months ago

Stalled at 12.5mg, changed nothing, and it started moving again on week 5. Very nearly went up. Glad I did not.

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u/pavel_nkemelu134 points·1 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/camila_mensa116 points·1 months ago

the sulphur burps passes. i promise. not medical advice.

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u/two_mil_or_oneOP0 points·1 months ago

Tried the split-dose thing for 22 weeks. Felt slightly smoother, lost at exactly the same rate. Went back to weekly.

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u/arne_amankwah1 point·1 months ago

my TSH moved before the scale did and i nearly missed it

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u/two_mil_or_oneOP0 points·1 months ago

titration speed is food noise plus side effects, period

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u/ffmi_watcher143 points·1 months ago

I am going to push back on this slightly.

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u/teodor_duarte65 points·1 months ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/units_not_mgsyringe math34 points·1 months ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/ravi_bergstrom12 points·1 months ago·edited

Respectfully this is a sample of one presented as a finding.

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u/test_it_yourselfvetting34 points·1 months ago

pens are overpriced, research vials are research grade, same molecule different price

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u/source_or_silence41 points·1 months ago·edited

Kept a public log for 85 weeks. The comments are what kept it going, honestly. Accountability from strangers works.

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u/marta_trevino51 points·1 months ago

Slight fix: the number was 98.7, not 98.9. Decimal point, but a fairly consequential one.

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u/hugo_bergstrom23 points·1 months ago

pens are overpriced, research vials are research grade, same molecule different price

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u/helga_vermeulen96 points·1 months ago

I am going to push back on this slightly.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/runa_wikstrom93 points·1 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/hugo_bergstrom0 points·1 months ago

nope, 0.25 counts, it is just not the dose most people stay on

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u/hamza_weiss54 points·1 months ago

I am going to push back on this slightly.

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u/oskar_ibarra23 points·1 months ago

the injection-site soreness passes. i promise. not medical advice.

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u/two_mil_or_one36 points·1 months ago

nope, 0.25 counts, it is just not the dose most people stay on

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u/greta_lokken17 points·1 months ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/two_mil_or_oneOP23 points·1 months ago

nope, 0.25 counts, it is just not the dose most people stay on

Yes, exactly this, and it is the bit that took me 67 weeks to accept.

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u/iman_castellanos27 points·1 months ago

My version: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part. Nobody believes that until they do it.

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u/coa_janitormod · c/coa9 points·1 months ago

Did you test the vial you received or are we going off the vendor COA?

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