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c/semaglutide·posted 9 days ago by u/helga_vermeulen

[PSA] 0.25 for four weeks is not a suggestion, it is the whole plan

PSA Clean Column ×1 Long Haul ×3

Confession thread, sort of.

I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 14 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 23 reads it before doing the same thing.

1,273 up / 340 down79% upvoted32 commentsid 1c81d721 Jul 2026

32 comments

16 in this archive, depth 4

best — the order this archive was captured in

u/titration_marshalmod · c/semaglutide181 points·8 days ago

Disagree. What you are describing is consistent with 2.4mg, not with what you concluded.

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u/units_not_mgMOD108 points·8 days ago·edited

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/nausea_notesside effects146 points·8 days ago·edited

Disagree.

Adding to this: weekly dosing is doing more work than the comment implies.

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u/anya_erdogan114 points·8 days ago

Hard agree. Week 29 me needed this. Week 78 me is nodding smugly.

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u/test_it_yourselfvetting91 points·7 days ago

titration speed is titration plus side effects, period

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u/ahmed_abubakar25 points·7 days ago

titration speed is titration plus side effects, period

Disagree on that part. 95.1% and 96.2% on the same vial is normal.

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u/slow_logbook_notes83 points·8 days ago

Cosigning. The slow route gets the outcome, the fast route gets you the side effects.

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u/plain_titration-36 points·8 days ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/helga_vermeulenOP1 point·7 days ago

Maintenance for 5 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/adaeze_brandt0 points·8 days ago

Hard agree. Week 40 me needed this. Week 89 me is nodding smugly.

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u/joaquin_stanescu29 points·7 days ago

week 4 on the pen, 32kg down, this is the answer

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u/leila_vasquez23 points·7 days ago

Not convinced. The evidence does not support that reading.

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u/helga_vermeulenOP12 points·7 days ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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u/ffmi_watcher37 points·8 days ago

Strongly agree. If it is not working at 12.5mg after 49 weeks, going up is not automatically the answer.

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u/ismael_chukwu27 points·7 days ago

the sulphur burps passes. i promise. not medical advice.

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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