the food noise question that gets asked weekly, answered properly
the food noise question that gets asked weekly, answered properly. Making the case below, and I expect to lose some of it in the comments. The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does. Steady state after a dose…
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Same injection day each week, or has it drifted?
Does constipation track the day after the shot, or is it there all week?
staying at 0.5mg for an extra month is a legitimate plan
What did week 93 look like compared with this one? The month either side is the useful comparison.
protein first, then everything else gets easier
nausea that arrives on day two and fades by day four is the standard shape
nausea that arrives on day two and fades by day four is the standard shape
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.