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c/semaglutide·submitted 9 days ago by u/sofia_wikstrom

the food noise going quiet is the part nobody warned me about

Metabranch of 9 comments

Thinking out loud about this: the food noise going quiet is the part nobody warned me about. On the "everybody ends up at 2.4" claim, which comes up every few weeks. The escalation schedule in the trials was designed to get people to a fixed study dose. Real use is not a trial. The dose that keeps your appetite quiet…

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9 comments, started 8 days ago
u/rafael_ostergaard142 points·8 days ago

The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.

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u/bilal_osei43 points·8 days ago

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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u/sofia_wikstromOP27 points·8 days ago

Cosigning.

Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.

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u/camila_sandvik11 points·7 days ago

Right, and the timescale is the bit that keeps getting lost.

Disagree with this specific line. A pause at 1.0mg is not evidence that 1.0mg has stopped working.

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u/sofia_wikstromOP25 points·8 days ago·edited

What dose and how many weeks at it before this started?

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u/sofia_wikstromOP0 points·7 days ago

Genuine question — is the appetite effect still there, or is it just the scale that has paused?

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u/camila_sandvik14 points·8 days ago

Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.

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u/leila_silva96 points·8 days ago

Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.

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