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c/semaglutide·submitted 1 year ago by u/pavel_nkemelu

[Meta] the 2.4mg rule is doing its job and people should stop complaining

Metabranch of 6 comments

the 2.4mg rule is doing its job and people should stop complaining, and it will stay as it is unless somebody makes the case to change it. The numbers the title promised, since a headline without them is worthless: 2.4mg. Everything below is context for those. Research-use-only material is not approved for human use,…

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6 comments, started 1 year ago
u/sofia_wikstrom352 points·1 year ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/nikhil_teixeira0 points·1 year ago

Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.

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u/prior_auth_painappeals290 points·1 year ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg.

sofia_wikstrom is describing the standard shape here and it matches the trial data better than most anecdotes do.

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u/zofia_lindholm69 points·1 year ago

the scale is the least sensitive instrument you own

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u/arne_amankwah78 points·1 year ago

How long was the stall before you decided it was a stall?

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u/kaplan_meier_kim54 points·1 year ago

How long was the stall before you decided it was a stall?

Disagree with this specific line. A pause at 1.7mg is not evidence that 1.7mg has stopped working.

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