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c/semaglutide·submitted 1 year ago by u/oskar_kaufmann

switched from 0.5mg to 1.0mg and muscle cramps got better, not worse

Questionbranch of 7 comments

Something I keep coming back to: switched from 0.5mg to 1.0mg and muscle cramps got better, not worse. Since the title puts numbers in the shop window: 0.5mg and 1.0mg. STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have…

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7 comments, started 1 year ago
u/arne_amankwah305 points·1 year ago

staying at 0.5mg for an extra month is a legitimate plan

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u/dose_creep_dan74 points·1 year ago

the food noise going quiet is the effect people actually describe

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u/helga_vermeulen20 points·1 year ago

The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.

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u/ines_castellanos189 points·1 year ago

Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.

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u/careful_gradient_again46 points·1 year ago

sema is weekly for a reason, the half-life does the smoothing

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u/oskar_kaufmann37 points·1 year ago

the first four weeks are a tolerance check, not a weight-loss phase

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u/niels_lindqvist65 points·1 year ago

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

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