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c/semaglutide·submitted 2 years ago by u/nikhil_teixeira

why does nobody talk about semaglutide

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why does nobody talk about semaglutide, and I want the answer with the reasoning attached rather than just the conclusion. The mental model that finally made this click for me: there are two curves, and people watch the wrong one. The first is exposure, which is set by the dose and smoothed by a week-long half-life.…

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11 comments, started 2 years ago

u/camila_mensa141 points·2 years ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/anya_salgado49 points·2 years ago·edited

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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u/vikram_ferreira26 points·2 years ago

STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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