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Single comment threadYou are looking at one branch of [Vendor] WWB vs QST on the same compound, same month — both cleared 98.5% — 49 comments in the full submission. View in context.
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c/semaglutide·submitted 2 years ago by u/micro_bump_mick

[Vendor] WWB vs QST on the same compound, same month — both cleared 98.5%

Titrationbranch of 11 comments

WWB vs QST on the same compound, same month — both cleared 98.5%. I will put the method line and the batch identifier up front because that is what makes this checkable. The relevant figures are 98.5%, and they come from the same log I have kept the whole time. Dropped my injection day by two days once because of…

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11 comments, started 2 years ago
u/leila_vasquez172 points·2 years ago

The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.

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u/georgi_haddad144 points·2 years ago

the ladder exists because the gut needs the time, not because the pharmacy likes paperwork

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u/zofia_lindholm43 points·2 years ago

the ladder exists because the gut needs the time, not because the pharmacy likes paperwork

Disagree with this specific line. A pause at 1.7mg is not evidence that 1.7mg has stopped working.

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u/two_mil_or_one21 points·2 years ago

Disagree with this specific line.

Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.

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u/arne_amankwah212 points·2 years ago

Sat at 0.5mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the early fullness.

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u/anya_salgado159 points·2 years ago

What dose and how many weeks at it before this started?

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u/arne_restrepo0 points·2 years ago

What dose and how many weeks at it before this started?

This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.

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u/ines_castellanos-25 points·2 years ago

Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the constipation usually fades at a stable dose.

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u/marta_trevino1 point·2 years ago

Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.

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u/hassan_castellanos56 points·2 years ago

week 59 plateau is the most predictable thing in this entire board

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u/lane_map_larrylogistics32 points·2 years ago·edited

week 59 plateau is the most predictable thing in this entire board

hassan_castellanos is describing the standard shape here and it matches the trial data better than most anecdotes do.

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