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c/retatrutide·submitted 3 months ago by u/ismael_eriksen

someone explain retatrutide to me like I have not read a paper in years

Labbranch of 8 comments

someone explain retatrutide to me like I have not read a paper in years. I would rather ask a basic question now than get this wrong quietly for two months. Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support…

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8 comments, started 3 months ago
u/incretin_ivyMOD357 points·3 months ago

Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.

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u/mateusz_mensah526 points·3 months ago

It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.

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u/solene_ilunga248 points·3 months ago

not approved anywhere, which is the single most important fact in this board

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u/two_mil_or_one378 points·3 months ago

phase 2 data only, and people quote it like it is a label

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u/priya_weiss80 points·3 months ago

Careful with the rankings. A phase 2 result and a phase 3 result are not on the same evidential footing and cannot be listed in one table.

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u/placebo_arm_pam58 points·3 months ago

the phase 2 numbers were striking and they were also 48 weeks in a small population

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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