[Results] 88 weeks on 2.4mg, full numbers, ask me anything boring
Six-word version is the title — 88 weeks on 2.4mg, full numbers, ask me anything boring — and the rest is context. Hard numbers: 88 weeks and 2.4mg. Anything softer than that is flagged as an impression. The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the…
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.
Careful with the rankings. A phase 2 result and a phase 3 result are not on the same evidential footing and cannot be listed in one table.
the escalation is where most of the reported trouble sits
Are you comparing against phase 3 numbers for something else? They are not comparable.
Is that the 48-week figure or an earlier readout?
Is that the 48-week figure or an earlier readout?
Agreed, and the glucagon arm is exactly why the comparison threads do not work.