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c/retatrutide·submitted 3 months ago by u/nadia_norgaard

the glucagon thing finally clicked for me and I want to write it down

Trial Databranch of 6 comments

Thinking out loud about this: the glucagon thing finally clicked for me and I want to write it down. Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part. Kept a log specifically because there is so little published. It is one person…

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6 comments, started 2 months ago
u/cold_chromatogram_only71 points·2 months ago

Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.

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u/zeynep_mbeki-12 points·2 months ago

triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part

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u/kavya_kravchenko-14 points·2 months ago

The muscle cramps profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.

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u/bilal_osei1 point·2 months ago

small trial, big effect, wide error bars

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u/trialwatch_theotrial nerd1 point·2 months ago

phase 2 data only, and people quote it like it is a label

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[removed]1 point·2 months ago

[removed by moderator]

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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