help me understand retatrutide, I have read the wiki twice
help me understand retatrutide, I have read the wiki twice. I am not trying to be the "source?" guy. I would just like a source. Where the evidence actually stands, since every thread here assumes a different answer. Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a…
Cosigning the escalation point. Almost every difficult report on this board is from somebody who went up quickly.
That is body weight change, not fat mass. The trials report the first and people quote it as the second.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation.
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
Cosigning the escalation point.
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
Push back: quoting the phase 2 headline as an expected outcome is not a fair reading of a small trial with wide intervals.
The thing that surprised me was how much of the discussion here is inference rather than measurement.
the energy-expenditure story is mechanistically interesting and clinically unproven
a lot of the confident posting here is extrapolation