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c/retatrutide·submitted 3 months ago by u/rohan_cardoso

how much of what we believe about dose escalation actually comes from glucagon threads

Cautionbranch of 6 comments

how much of what we believe about dose escalation actually comes from glucagon threads, and I want the answer with the reasoning attached rather than just the conclusion. Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered…

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6 comments, started 3 months ago
u/yannick_barros138 points·3 months ago

Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.

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u/incretin_ivypharmacology64 points·3 months ago

the glucagon component is why the metabolic story reads differently

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u/employer_carveout90 points·3 months ago·edited

heart rate is the thing people report watching

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u/reflux_report39 points·3 months ago

the escalation is where most of the reported trouble sits

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u/incretin_ivypharmacology55 points·3 months ago

nothing here is available as a prescription product, so read every thread with that in mind

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u/rohan_cardosoOP33 points·3 months ago

Sent a vial to VendorInvestigate out of curiosity. Result was 97.7% against a claimed 97.5%, which is the first independent number I had seen for this compound anywhere.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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