week 21 check-in — 8kg down, fatigue manageable, one thing confusing me
week 21 check-in — 8kg down, fatigue manageable, one thing confusing me. Posting the boring middle of the process, because the internet is full of the start and the end and nothing else. Numbers, in the order they matter: week 21 and 8kg. The standing caveat, written out properly because it keeps getting compressed…
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.
This. The phase 2 result was genuinely large and it was also 48 weeks in a few hundred people.
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
Removed the escalation schedule. There is no published protocol for members to follow and inventing one here is exactly what this board does not do.
comparing reta phase 2 to sema phase 3 is comparing different things
the energy-expenditure story is mechanistically interesting and clinically unproven
phase 2 data only, and people quote it like it is a label
wait for phase 3 before you argue about rankings
the glucagon component is why the metabolic story reads differently