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c/retatrutide·submitted 3 months ago by u/lina_bruun

[Meta] proposal — a flair for phase 2 posts

Cautionbranch of 6 comments

proposal — a flair for phase 2 posts. Disagreement welcome, but bring a concrete alternative wording. Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish. Phase 2 estimates effect and finds a dose range. Phase…

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6 comments, started 3 months ago

u/ismael_eriksen129 points·3 months ago

small trial, big effect, wide error bars

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u/lina_bruunOP188 points·3 months ago

Stopped at a low step because there was no reason to go further and no data to tell me what further would do.

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u/lina_bruunOP-6 points·3 months ago

phase 2 data only, and people quote it like it is a label

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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Independent HPLC and mass spec. The number you get is the number they found.

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c/retatrutide rules

Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
Heart-rate and dose-escalation reports need actual measurements, not impressions.
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