the TRIUMPH thing finally clicked for me and I want to write it down
The title is the argument: the TRIUMPH thing finally clicked for me and I want to write it down. Here is the rest of it.
Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.
Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.
Happy to answer the boring questions. Those are usually the ones worth asking.
best — the order this archive was captured in
Removed the escalation schedule. There is no published protocol for members to follow and inventing one here is exactly what this board does not do.
nothing here is available as a prescription product, so read every thread with that in mind
The thing that surprised me was how much of the discussion here is inference rather than measurement.
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the energy-expenditure story is mechanistically interesting and clinically unproven
Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.
the phase 2 numbers were striking and they were also 48 weeks in a small population
Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation.
liver_enzyme_liz is right about the escalation being the variable. It explains most of the difficult reports here.
liver_enzyme_liz is right about the escalation being the variable.
This is the sentence the rest of the board should read first. Phase 2 is not a label.
That reads as a titration plan for an unapproved compound. This board cannot host that and it should not want to.
- 1nothing here is available as a prescription product, so read every thread…7 comments in this branch · started by u/careful_gradient_again