[Meta] the retatrutide rule is doing its job and people should stop complaining
the retatrutide rule is doing its job and people should stop complaining. Short post, long comment section, probably. Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict. Sent a vial…
Not convinced. You are attributing a week of constipation to the glucagon arm when the escalation rate alone would explain it.
dose escalation in the trials was slow for a reason
the energy-expenditure story is mechanistically interesting and clinically unproven
The thing that surprised me was how much of the discussion here is inference rather than measurement.
How fast was the escalation? That is usually the variable that explains the reports.
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.