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c/retatrutide·submitted 2 years ago by u/ferran_krastev

retatrutide — my 21-week log, condensed into one table

Cautionbranch of 6 comments

retatrutide — my 21-week log, condensed into one table. I have gone back and forth on this for months. Where the evidence actually stands, since every thread here assumes a different answer. Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow, protocol-driven…

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6 comments, started 2 years ago
u/hassan_nilsen15 points·2 years ago

The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.

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u/ferran_krastevOP7 points·2 years ago

The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation.

Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.

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u/ferran_krastevOP4 points·2 years ago

Is that the 48-week figure or an earlier readout?

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u/baseline_drifteranalytical9 points·2 years ago

heart rate is the thing people report watching

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u/nadia_trevino3 points·2 years ago·edited

comparing reta phase 2 to sema phase 3 is comparing different things

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u/blunt_coldbox_202412 points·2 years ago

heart rate is the thing people report watching

Adding the standing caveat: none of this is approved anywhere and research material is not for human use.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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