retatrutide — my 21-week log, condensed into one table
retatrutide — my 21-week log, condensed into one table. I have gone back and forth on this for months.
Where the evidence actually stands, since every thread here assumes a different answer.
Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow, protocol-driven escalation. The effect size was striking. The confidence intervals were wide, the population was small, and the duration was under a year.
Phase 3 is running. Until it reports, everything else — including the ranking arguments this board loves — is extrapolation from a small study. That is not a criticism of the compound; it is a description of the evidence.
Kept a log specifically because there is so little published. It is one person and it is not data.
The thing that surprised me was how much of the discussion here is inference rather than measurement.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation.
Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.
Is that the 48-week figure or an earlier readout?
heart rate is the thing people report watching
comparing reta phase 2 to sema phase 3 is comparing different things
heart rate is the thing people report watching
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
Stopped at a low step because there was no reason to go further and no data to tell me what further would do.
Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.
research-use-only material is not approved for human use, full stop
Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.
Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.
dose escalation in the trials was slow for a reason
- 1The phase 2 readout ran to 48 weeks in a few hundred participants with a…6 comments in this branch · started by u/hassan_nilsen
- 2Stopped at a low step because there was no reason to go further and no data…6 comments in this branch · started by u/source_or_silence