[Results] 26 weeks, 5kg, and dose escalation was the hard part
26 weeks, 5kg, and dose escalation was the hard part. Same spreadsheet I have been keeping since the start, nothing retrofitted.
Figures up front so nobody has to dig: 26 weeks and 5kg.
Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.
It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.
Ask me anything specific. Anything general I will probably get wrong.
best — the order this archive was captured in
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
nothing here is available as a prescription product, so read every thread with that in mind
Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.
The standing caveat, written out properly because it keeps getting compressed into a footnote.
Nothing containing this compound is approved by any regulator. Research-use-only material is not approved for human use. That is not a legal formality on this board — it is why there is so little independent data, why the escalation schedules people post are invented, and why nobody here can answer a dosing question.
What this board can usefully do is read the published trials carefully, log independent purity results, and be honest about how thin the evidence base is. Everything else belongs somewhere with a clinician in it.
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wait for phase 3 before you argue about rankings
What is the source for that figure — the published paper or a summary of it?
Flair set to Trial Data since the post is about the published readout rather than an experience.
Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.
comparing reta phase 2 to sema phase 3 is comparing different things
comparing reta phase 2 to sema phase 3 is comparing different things
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
heart rate is the thing people report watching
the escalation is where most of the reported trouble sits
Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.
Which phase 2 arm are you quoting, and at what week?
Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.
The thing that surprised me was how much of the discussion here is inference rather than measurement.
Are you comparing against phase 3 numbers for something else? They are not comparable.
Agreed on the heart-rate reports. They are consistent enough across the threads to be worth noting, not enough to be a finding.
Stopped at a low step because there was no reason to go further and no data to tell me what further would do.
dose escalation in the trials was slow for a reason
Push back: quoting the phase 2 headline as an expected outcome is not a fair reading of a small trial with wide intervals.
Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
Is that the 48-week figure or an earlier readout?
the energy-expenditure story is mechanistically interesting and clinically unproven
small trial, big effect, wide error bars
Kept a log specifically because there is so little published. It is one person and it is not data.
Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.
- 1Yes — the comparison threads are apples to oranges and they generate more…7 comments in this branch · started by u/anya_moreau
- 2Flair set to Trial Data since the post is about the published readout rather…6 comments in this branch · started by u/lane_watcher