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c/retatrutide·submitted 2 years ago by u/noor_ivaturi

what changed for me between month 8 and month 16

Cautionbranch of 7 comments

what changed for me between month 8 and month 16, and I want the answer with the reasoning attached rather than just the conclusion. Sent a vial to Medutest out of curiosity. Result was 99.2% against a claimed 98.5%, which is the first independent number I had seen for this compound anywhere. The thing that surprised…

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7 comments, started 2 years ago
u/honest_syringe33140 points·2 years ago

Is that the 48-week figure or an earlier readout?

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u/sofia_wikstrom92 points·2 years ago

the energy-expenditure story is mechanistically interesting and clinically unproven

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u/viktor_laurent51 points·2 years ago

That is body weight change, not fat mass. The trials report the first and people quote it as the second.

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u/trialwatch_theotrial nerd41 points·2 years ago

small trial, big effect, wide error bars

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u/ferran_krastev115 points·2 years ago·edited

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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u/blunt_coldbox_202441 points·2 years ago

heart rate is the thing people report watching

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u/titration_marshalmod · c/semaglutide26 points·2 years ago

Right, and it bears repeating that nothing here is approved anywhere and research material is not for human use.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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