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Single comment threadYou are looking at one branch of my A1c moved and I cannot work out whether TRIUMPH is why — 33 comments in the full submission. View in context.
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c/retatrutide·submitted 9 months ago by u/andres_sorensen

my A1c moved and I cannot work out whether TRIUMPH is why

Cautionbranch of 9 comments

Thinking out loud about this: my A1c moved and I cannot work out whether TRIUMPH is why. Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer. Independent purity testing on this compound is thin…

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9 comments, started 9 months ago
u/soren_nkemelu37 points·9 months ago

Which phase 2 arm are you quoting, and at what week?

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u/marit_laurent10 points·9 months ago

Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.

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u/hassan_nilsen5 points·9 months ago

not approved anywhere, which is the single most important fact in this board

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u/nadia_trevino13 points·9 months ago·edited

Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.

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u/andres_sorensenOP6 points·9 months ago

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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u/rekha_vestergaard7 points·9 months ago

research-use-only material is not approved for human use, full stop

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u/soren_nkemelu4 points·9 months ago

Kept a log specifically because there is so little published. It is one person and it is not data.

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u/cormac_roos13 points·9 months ago

triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part

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u/nadia_norgaard8 points·9 months ago

triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part

Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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