[Lab] 9th independent test on QYB — 97.7% on a claimed 97.0%, and the trend is the interesting part
Filing this under things worth writing down: 9th independent test on QYB — 97.7% on a claimed 97.0%, and the trend is the interesting part. Numbers, in the order they matter: 97.7% and 97.0%. Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the…
It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.
It is a triple agonist at the GLP-1, GIP and glucagon receptors.
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.
the TRIUMPH programme is still running, so anything definitive is premature
the escalation is where most of the reported trouble sits
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.
Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.