[Question] TRIUMPH — what am I missing here
TRIUMPH — what am I missing here. If this has been answered properly somewhere, link me and I will delete. Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part. The fatigue profile felt different rather than worse. Hard to describe and…
comparing reta phase 2 to sema phase 3 is comparing different things
It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.
Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.
Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.
Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
nothing here is available as a prescription product, so read every thread with that in mind
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.
Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding.