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Single comment threadYou are looking at one branch of [Question] why is reta purity testing so much more variable between labs — 29 comments in the full submission. View in context.
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c/retatrutide·submitted 11 days ago by u/burned_once_twice

[Question] why is reta purity testing so much more variable between labs

Questionbranch of 6 comments

Genuine question, and the title is the question: why is reta purity testing so much more variable between labs. The constipation profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression. Independent purity testing on this compound is thin compared with the…

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6 comments, started 11 days ago
u/dead_space_doug56 points·11 days ago

Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.

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u/renzo_yildiz-28 points·11 days ago

the TRIUMPH programme is still running, so anything definitive is premature

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u/burned_once_twiceOP1 point·10 days ago

Is that the 48-week figure or an earlier readout?

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u/janek_ferrari1 point·10 days ago

research-use-only material is not approved for human use, full stop

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u/yannick_barros1 point·10 days ago

Is that the 48-week figure or an earlier readout?

Agreed, and the glucagon arm is exactly why the comparison threads do not work.

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u/ewan_marchand1 point·10 days ago

Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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