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c/retatrutide·posted 1 year ago by u/soren_nkemelu

[Question] triple agonist — what am I missing here

Question

Trying to get a straight answer on this: triple agonist — what am I missing here.

Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.

Sent a vial to Medutest out of curiosity. Result was 99.6% against a claimed 99.0%, which is the first independent number I had seen for this compound anywhere.

The thing that surprised me was how much of the discussion here is inference rather than measurement.

That is everything I have. The rest is opinion and I have tried to keep it out.

0 up / 0 down40% upvoted9 commentsid 1vpwbm7 Nov 2024

9 comments

9 in this archive, depth 5

best — the order this archive was captured in

u/quiet_moderatormod2 points·1 year ago

The standing caveat, written out properly because it keeps getting compressed into a footnote.

Nothing containing this compound is approved by any regulator. Research-use-only material is not approved for human use. That is not a legal formality on this board — it is why there is so little independent data, why the escalation schedules people post are invented, and why nobody here can answer a dosing question.

What this board can usefully do is read the published trials carefully, log independent purity results, and be honest about how thin the evidence base is. Everything else belongs somewhere with a clinician in it.

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u/soren_nkemeluOP1 point·1 year ago

Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding.

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u/dead_space_doug-35 points·1 year ago

Which phase 2 arm are you quoting, and at what week?

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u/soren_nkemeluOP1 point·1 year ago

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

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u/vito_beaulieu0 points·1 year ago

Small fix — three receptors, not two.

Adding the standing caveat: none of this is approved anywhere and research material is not for human use.

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u/kavya_kravchenko1 point·1 year ago

the glucagon component is why the metabolic story reads differently

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u/quiet_moderatormod1 point·1 year ago

not approved anywhere, which is the single most important fact in this board

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u/soren_nkemeluOP1 point·1 year ago

Are you tracking heart rate at all?

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u/two_mil_or_one1 point·1 year ago

research-use-only material is not approved for human use, full stop

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
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