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c/retatrutide·submitted 2 years ago by u/ewan_marchand

[Results] 45 weeks on 10mg, full numbers, ask me anything boring

Resultsbranch of 6 comments

45 weeks on 10mg, full numbers, ask me anything boring, and the part I actually want to talk about is at the bottom. Pulling the figures out of the title: 45 weeks and 10mg. All of it is written down as it happened rather than reconstructed. Nothing containing this compound is approved anywhere. Research-use-only…

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6 comments, started 2 years ago
u/viktor_laurent32 points·2 years ago

Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.

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u/renzo_yildiz-15 points·2 years ago

wait for phase 3 before you argue about rankings

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u/matias_falk1 point·2 years ago

Is that the 48-week figure or an earlier readout?

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u/kofi_balogun1 point·2 years ago

comparing reta phase 2 to sema phase 3 is comparing different things

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u/andres_sorensen1 point·2 years ago

The constipation profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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