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c/retatrutide·submitted 2 years ago by u/discount_math_dm

is it normal to get sulphur burps at week 24

Discussionbranch of 7 comments

is it normal to get sulphur burps at week 24. Full detail below, and I have tried to keep the editorialising out of it. The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number. Glucagon receptor agonism is…

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7 comments, started 2 years ago
u/kavya_kravchenko137 points·2 years ago

Has anyone posted an independent test on this compound recently?

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u/careful_gradient3277 points·2 years ago

Has anyone posted an independent test on this compound recently?

Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.

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u/janek_ferrari20 points·2 years ago

wait for phase 3 before you argue about rankings

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u/bilal_osei6 points·2 years ago

comparing reta phase 2 to sema phase 3 is comparing different things

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u/discount_math_dmOP81 points·2 years ago

Sent a vial to Janoshik out of curiosity. Result was 98.4% against a claimed 97.5%, which is the first independent number I had seen for this compound anywhere.

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u/bastian_ekstrom50 points·2 years ago

Sent a vial to Janoshik out of curiosity.

discount_math_dm is right about the escalation being the variable. It explains most of the difficult reports here.

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u/trialwatch_theoMOD57 points·2 years ago

Trial names corrected in the title. The phase 3 programme and the phase 2 readout are not the same thing.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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