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c/reconstitution·posted 4 days ago by u/dilara_szabo

foam means you shook it. do not shake it

Correction Well Actually ×8 Slow Clap ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking insulin syringe against eGFR for 15 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

2,224 up / 820 down73% upvoted29 commentsid kbmcc425 Jul 2026

29 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/niels_roos214 points·3 days ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/santiago_ndiaye182 points·3 days ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/units_not_mgMOD149 points·3 days ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/marta_weiss68 points·2 days ago·edited

Cosigning. The concentration on the vial in marker is load-bearing.

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u/sock_puppet_spotter30 points·2 days ago·edited

show your working or it is unhelpful

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u/escrow_evangelist33 points·3 days ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/hedda_adeyemi73 points·2 days ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/santiago_ndiaye50 points·2 days ago·edited

the concentration on the vial in marker is the most important step

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u/lurker_for_years15 points·2 days ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/dilara_szaboOP28 points·2 days ago

Reconstituted at 2mL when I meant 11mL. Caught it because the units looked wrong. Write the concentration.

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u/kavya_radich65 points·3 days ago

The confident tone is doing a lot of work that the evidence is not.

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u/dilara_szaboOP37 points·3 days ago

dead space is real and the syringe matters

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u/oskar_ibarra72 points·3 days ago

show your working or it is unhelpful

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u/ledger_modmod · vetting36 points·4 days ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/ismael_nwosu30 points·3 days ago

Half-life is about 168 hours, so steady state lands around week 5–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/soren_zamora14 points·3 days ago

That is net peptide content, not purity. Different number, different meaning.

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u/dilara_szaboOP8 points·3 days ago

dead space is real and the syringe matters

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u/india_generic_g21 points·2 days ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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