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c/reconstitution·submitted 5 days ago by u/ilias_cabrera

[Explainer] why 1mL syringes cause overdoses and 0.3mL ones do not

Explainerbranch of 6 comments

why 1mL syringes cause overdoses and 0.3mL ones do not. If you already knew this, the post is not for you and you can scroll on. 1mL and 0.3mL. Those are measured, not estimated, and not rounded up in my favour. Spent 17 weeks confused about this until somebody drew the table for me. 5mg, 1mL, 5mg/mL, 2mg is 40…

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6 comments, started 3 days ago
u/marisol_frisk29 points·3 days ago

Asked HJ what volume they reconstitute to for their own stability testing and they answered in one line. Useful thing to know.

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u/dexa_twice_yearlybody comp34 points·3 days ago

twice as much water halves the concentration and doubles the units for the same dose

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u/gradient_goblin20 points·3 days ago

more water is not more drug, it is the same drug in a bigger volume

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u/soren_zamora-16 points·3 days ago

Adding more water does not change how much peptide is in the vial. It changes the concentration, which changes the volume you draw for the same amount. That is the entire relationship.

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u/emil_okwuosa11 points·3 days ago

more water is not more drug, it is the same drug in a bigger volume

This is the sentence that makes the rest unnecessary. Write it on the vial and the problem is gone.

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u/emil_wojcik14 points·3 days ago

This. Showing the working is the fastest way for somebody else to spot the mistake.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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