[Explainer] why 1mL syringes cause overdoses and 0.3mL ones do not
Genuinely asking, not being difficult.
Everyone in c/orforglipron repeats that dead space is important. I believe it, but I have never seen anyone show why, and when I search I get 17 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
more water means more units for the same dose, which means finer resolution
more water means more units for the same dose, which means finer resolution
Adding to this: concentration is doing more work than the comment implies.
That is net peptide content, not purity. Different number, different meaning.
the concentration on the vial in marker is the most important step
swirl, do not shake, or you are courting oxidation
This is correct. 1mL versus 15mL is the common mistake.
This is the "correlation is mechanism" thing again. You changed three variables at once.
Respectfully this is a sample of one presented as a finding.
Titration speed is a side-effect dial far more than an efficacy dial.
dosing errors come from people reconstituting two vials differently and forgetting which is which
Reconstituted at 2mL when I meant 10mL. Caught it because the units looked wrong. Write the concentration.
dosing errors come from people reconstituting two vials differently and forgetting which is which
Disagree on that part. 97.9% and 97.6% on the same vial is normal.
20mg vial, 2mL water, concentration is 20/2 — write it on the vial afterwards
u-100 syringe, not u-40, or your math is off by factor of 21
10mg vial, 2mL water, concentration is 10/2 — write it on the vial afterwards
30mg vial, 1mL water, concentration is 30/1 — write it on the vial afterwards
swirl, do not shake, or you are courting oxidation
20mg vial, 2mL water, concentration is 20/2 — write it on the vial afterwards
dead space is real and the syringe matters
[deleted]
never post a calculation as advice without stating the concentration
bacteriostatic and sterile water are not interchangeable, do not use them that way
Disagree. What you are describing is consistent with bacteriostatic water, not with what you concluded.
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
Inter-lab variance on this kind of assay is routinely 1–2 points.
Yes, exactly this, and it is the bit that took me 6 weeks to accept.
That is net peptide content, not purity. Different number, different meaning.
dead space is real and the syringe matters
- 1dosing errors come from people reconstituting two vials differently and…9 comments in this branch · started by u/britta_nakamura
- 2more water means more units for the same dose, which means finer resolution8 comments in this branch · started by u/arne_restrepo