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c/reconstitution·submitted 2 years ago by u/marta_weiss

how much of what we believe about reconstitution actually comes from concentration threads

PSAbranch of 7 comments

how much of what we believe about reconstitution actually comes from concentration threads. If this has been answered properly somewhere, link me and I will delete. The failure modes I have actually seen posted here, in order of frequency. One: reconstituting at a different volume than intended and not writing it…

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7 comments, started 2 years ago
u/janek_ferrari642 points·2 years ago·edited

Not quite. Bacteriostatic and sterile water are not interchangeable for a multi-draw vial, and the difference is the preservative.

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[deleted]467 points·2 years ago

[deleted]

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u/sleep_apnea_sam677 points·2 years ago

Started reconstituting everything to a round concentration and the six-in-the-morning error rate went to zero.

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u/karl_fischer_kev158 points·2 years ago

I would not round that figure. At 5mg/mL a rounding error of two units is a real fraction of the intended amount.

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u/yusuf_nakamura99 points·2 years ago

How many mg in the vial and how many mL are you adding?

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u/rasmus_mensah81 points·2 years ago

if the maths gives you a fraction of a unit, change the concentration

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u/lyophile_lou37 points·2 years ago

more water is not more drug, it is the same drug in a bigger volume

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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