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c/reconstitution·submitted 8 months ago by u/quiet_reader_99

how much of what we believe about concentration actually comes from mg/mL threads

Questionbranch of 9 comments

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about concentration actually comes from mg/mL threads. Why "more water" keeps confusing people, including me for a month. The vial contains a fixed amount of peptide. Water changes nothing about that amount. What it…

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9 comments, started 8 months ago
u/runa_cabrera152 points·8 months ago

do the arithmetic before you reconstitute, not while holding a syringe

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u/quiet_reader_99OP97 points·8 months ago

reconstituting at a round concentration makes every later dose easy

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u/dexa_twice_yearlybody comp32 points·8 months ago

more water is not more drug, it is the same drug in a bigger volume

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u/karim_ilunga11 points·8 months ago

Agreed — units are volume. Once that lands, the rest of the arithmetic is one division.

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u/rasmus_mensah62 points·8 months ago

Correction: that gives 20 units, not what you have written. 5mg into 1mL is 5mg/mL and the division follows from there.

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u/tl_dr_tina22 points·8 months ago

swirl, never shake

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u/escrow_evangelist11 points·8 months ago

Right — the volume you add is the only variable you control here, and the cake does not change it meaningfully.

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u/batch_number_bertievetting9 points·8 months ago

if the maths gives you a fraction of a unit, change the concentration

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[removed]17 points·8 months ago

[removed by moderator]

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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