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c/reconstitution·submitted 2 months ago by u/yusuf_nakamura

unpopular opinion: most of what gets said here about insulin syringe is guesswork

Explainerbranch of 10 comments

unpopular opinion: most of what gets said here about insulin syringe is guesswork — a position I have arrived at slowly and would like tested. Aim the stream down the wall of the vial rather than into the cake. Reconstitution is a solubility problem, not a mixing problem, and mechanical shear does nothing helpful.…

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10 comments, started 2 months ago
u/marta_weiss0 points·2 months ago

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

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u/kenji_kimani1 point·2 months ago

units are a volume on a U-100 syringe, not a dose

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u/zaid_balogun1 point·2 months ago

That only works if the fill weight is exactly the label weight, and it usually is not exactly anything.

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u/oskar_kaufmann0 points·2 months ago

bacteriostatic water has the preservative, sterile water does not

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u/andres_sorensen1 point·2 months ago

15mg into 3mL is 5mg/mL, and 2mg of that is 40 units

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u/yusuf_nakamuraOP1 point·2 months ago

That is sterile water, not bacteriostatic. Same appearance, different product, and it matters for a multi-draw vial.

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u/yusuf_achebe1 point·2 months ago

That is sterile water, not bacteriostatic.

Right, and the arithmetic behind it: 15mg in 3mL is 5mg/mL, so 2mg is 40 units.

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u/ilias_cabrera1 point·2 months ago

more water is not more drug, it is the same drug in a bigger volume

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u/lurker_for_years1 point·2 months ago

Agreed on the swirl. There is no reason to shake it and a good reason not to.

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u/yusuf_nakamuraOP1 point·2 months ago

do the arithmetic before you reconstitute, not while holding a syringe

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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