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c/reconstitution·submitted 2 months ago by u/reflux_report

does bacteriostatic water actually matter or is it forum lore at this point

Discussionbranch of 10 comments

Genuine question, and the title is the question: does bacteriostatic water actually matter or is it forum lore at this point. Asked JEEP what volume they reconstitute to for their own stability testing and they answered in one line. Useful thing to know. Started reconstituting everything to a round concentration and…

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10 comments, started 2 months ago
u/ahmed_rasmussen72 points·2 months ago

If your calculation produces a fraction of a unit, the concentration is wrong for your dose. Change the water volume until the numbers land on whole units.

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u/signe_grimaldi48 points·2 months ago·edited

What is written on the vial right now?

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u/mateusz_achebe-28 points·2 months ago

20mg into 2mL is 10mg/mL, and 5mg of that is 50 units

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u/reflux_reportOP1 point·2 months ago

label the vial with the date as well as the concentration

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u/bac_water_banditreconstitution1 point·2 months ago

more water is not more drug, it is the same drug in a bigger volume

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u/spain_receta1 point·2 months ago

bacteriostatic water has the preservative, sterile water does not

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[deleted]26 points·2 months ago

[deleted]

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u/adaeze_cabrera20 points·2 months ago

That only works if the fill weight is exactly the label weight, and it usually is not exactly anything.

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u/reflux_reportOP40 points·2 months ago

Is that a U-100 syringe? The barrel markings change the answer completely.

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u/runa_cabrera19 points·2 months ago

Aim the stream down the wall of the vial rather than into the cake. Reconstitution is a solubility problem, not a mixing problem, and mechanical shear does nothing helpful.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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