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c/reconstitution·posted 3 months ago by u/saskia_rahimi

how much of what we believe about units actually comes from dead space threads

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Genuine question, and the title is the question: how much of what we believe about units actually comes from dead space threads.

Spent 12 weeks confused about this until somebody drew the table for me. 15mg, 3mL, 5mg/mL, 0.75mg is 15 units. That is the whole thing.

Wrote the date on the vial as well as the concentration after losing track of which one was opened first.

Started reconstituting everything to a round concentration and the six-in-the-morning error rate went to zero.

Would rather be corrected in public than confident in private.

4,452 up / 627 down88% upvoted46 commentsid 41uxg328 Apr 2026

46 comments

12 in this archive, depth 3

best — the order this archive was captured in

u/runa_grimaldi607 points·3 months ago

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

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u/julia_erdogan889 points·3 months ago

If your calculation produces a fraction of a unit, the concentration is wrong for your dose. Change the water volume until the numbers land on whole units.

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u/lurker_for_years521 points·3 months ago

the number you write down is the number you will trust at 6am

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u/ilias_cabrera0 points·3 months ago

Bacteriostatic water contains benzyl alcohol as a preservative, which is what makes repeated entry into the same vial reasonable. Plain sterile water has no preservative.

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[removed]1 point·3 months ago

[removed by moderator]

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u/saskia_rahimiOP1 point·3 months ago

Small fix — a U-100 syringe is 100 units per mL. If yours is marked differently it is not U-100 and the whole calculation changes.

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u/iman_falk238 points·3 months ago

swirl, never shake

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u/alcohol_aversion-33 points·3 months ago

Reconstituted at 1mL when I meant to use a different volume. Caught it because the units looked wrong on the barrel. Now I write 5mg/mL on the glass before I put the cap back.

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u/mateusz_achebe0 points·3 months ago

Reconstituted at 1mL when I meant to use a different volume.

This is the sentence that makes the rest unnecessary. Write it on the vial and the problem is gone.

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u/erez_perrin158 points·3 months ago

The dead space question sent me down a rabbit hole for a week. It is a fraction of a unit and it is the same every draw.

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u/batch_number_bertievetting130 points·3 months ago

the powder cake sits at the bottom, the volume you add is the volume that counts

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u/units_not_mgsyringe math124 points·3 months ago·edited

That only works if the fill weight is exactly the label weight, and it usually is not exactly anything.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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