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c/reconstitution·submitted 2 years ago by u/sigrid_kaufmann

reading concentration threads from 2024 and half of it aged badly

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reading concentration threads from 2024 and half of it aged badly — a position I have arrived at slowly and would like tested. Aim the stream down the wall of the vial rather than into the cake. Reconstitution is a solubility problem, not a mixing problem, and mechanical shear does nothing helpful. Reconstituted at…

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9 comments, started 2 years ago
u/emeka_delgado181 points·2 years ago

If your calculation produces a fraction of a unit, the concentration is wrong for your dose. Change the water volume until the numbers land on whole units.

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[deleted]133 points·2 years ago

[deleted]

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u/nabila_espinoza58 points·2 years ago

the number you write down is the number you will trust at 6am

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u/honest_syringe_maybe0 points·2 years ago

the number you write down is the number you will trust at 6am

Disagreeing with this line only: adding more water is not a safety margin, it is a different divisor.

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The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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