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c/reconstitution·submitted 1 year ago by u/niels_roos

bacteriostatic water is the most under-discussed thing on this board

PSAbranch of 7 comments

bacteriostatic water is the most under-discussed thing on this board. Not a hot take, just something I have not seen said plainly here. Wrote the date on the vial as well as the concentration after losing track of which one was opened first. Shook the first vial because nobody told me not to. It was fine, but I have…

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7 comments, started 1 year ago
u/julia_erdogan828 points·1 year ago

swirl, never shake

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u/rasmus_kuipers402 points·1 year ago

Pushback on the syringe advice: a U-100 barrel reads units of volume. Calling them "doses" is how the confusion starts.

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u/iman_falk157 points·1 year ago

write the concentration on the vial in marker, that is the whole post

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u/dexa_twice_yearlybody comp203 points·1 year ago

Right — the volume you add is the only variable you control here, and the cake does not change it meaningfully.

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u/piotr_bruun347 points·1 year ago

Agreed on the swirl. There is no reason to shake it and a good reason not to.

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u/ilias_steiner225 points·1 year ago

I would not round that figure. At 5mg/mL a rounding error of two units is a real fraction of the intended amount.

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u/honest_syringe_maybe626 points·1 year ago

The whole calculation, once, with real numbers.

You have a 20mg vial. You add 3mL of bacteriostatic water. Concentration is mass over volume: 6.67mg/mL. A U-100 insulin syringe is graduated at 100 units per millilitre, so one unit is 0.01mL.

To draw 5mg you need 5 divided by 6.67 millilitres, which is 75 units on the barrel. Write "6.67mg/mL" on the vial in marker before you put it away, and you never have to do this again for that vial.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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