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c/reconstitution·submitted 1 year ago by u/emil_okwuosa

the bacteriostatic water question that gets asked weekly, answered properly

PSAbranch of 7 comments

the bacteriostatic water question that gets asked weekly, answered properly. Change my mind, genuinely — I have no stake in being right about this. The failure modes I have actually seen posted here, in order of frequency. One: reconstituting at a different volume than intended and not writing it down, so the next…

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7 comments, started 1 year ago
u/niels_roos81 points·1 year ago

This. Showing the working is the fastest way for somebody else to spot the mistake.

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u/emil_okwuosaOP53 points·1 year ago

Small fix — a U-100 syringe is 100 units per mL. If yours is marked differently it is not U-100 and the whole calculation changes.

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u/rasmus_mensah75 points·1 year ago

Started reconstituting everything to a round concentration and the six-in-the-morning error rate went to zero.

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u/india_generic_g22 points·1 year ago

the number you write down is the number you will trust at 6am

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u/yusuf_nakamura15 points·1 year ago

label the vial with the date as well as the concentration

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u/anya_antonsen67 points·1 year ago

The lyophilised cake displaces a small volume, so the true concentration is very slightly lower than the arithmetic suggests. It is a fraction of a percent and it is dwarfed by fill tolerance.

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u/emil_okwuosaOP34 points·1 year ago

That is sterile water, not bacteriostatic. Same appearance, different product, and it matters for a multi-draw vial.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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