[Results] 55 weeks on 5mg, full numbers, ask me anything boring
Reporting in. 55 weeks on 5mg, full numbers, ask me anything boring.
The relevant figures are 55 weeks and 5mg, and they come from the same log I have kept the whole time.
Holding off on any opinion until phase 3 reports. That is not a satisfying position and it is the honest one.
Why "oral" is doing two completely different jobs in the sentences people write here.
Oral semaglutide is a peptide co-formulated with an absorption enhancer, which is why it comes with food and water timing requirements. This compound is a non-peptide small molecule that activates the same receptor, formulated as an ordinary tablet.
The practical consequences differ enormously: no timing constraints, a conventional manufacturing route, different stability behaviour, and a different analytical problem for anybody trying to verify identity or purity. Whenever a thread here compares the two, check which sense of "oral" each half is using.
I will update this if the picture changes rather than quietly leaving it up.
best — the order this archive was captured in
It is a non-peptide small-molecule agonist at the GLP-1 receptor. That is a substantial medicinal chemistry achievement: getting a small molecule to activate a receptor evolved for a peptide ligand.
Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.
nothing containing this is approved anywhere and research material is not for human use
Read both programme names carefully after mixing them up in a comment and being politely corrected.
Correction: that is the oral peptide product, which is a different thing entirely. This one is a small molecule.
Went looking for independent testing on this and found essentially nothing, which was clarifying.
Push back: daily dosing is not automatically better adherence. It is a different failure mode, not a solved problem.
- 1Analytically this is a small-molecule identity and purity problem, not a…6 comments in this branch · started by u/hedda_ekstrom