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c/orforglipron·posted 14 days ago by u/freya_marchand

[Discussion] non-peptide agonism is a genuinely different engineering problem

Discussion Long Haul ×4

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking orforglipron against ApoB for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

398 up / 76 down84% upvoted10 commentsid mzty6016 Jul 2026

10 comments

4 in this archive, depth 2

best — the order this archive was captured in

u/kenji_laurent-12 points·13 days ago

oral non-peptide agonist is ACHIEVE, no food restrictions

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u/muscle_cramp_mo25 points·13 days ago

This is correct. ATTAIN data is phase 22.

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u/hedda_ekstrom0 points·13 days ago

Small correction: the trial was 11 weeks, not 12. Does not change your point but people will quote it.

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u/hamza_weiss13 points·12 days ago

The confident tone is doing a lot of work that the evidence is not.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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