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c/orforglipron·posted 1 year ago by u/hsa_math

[Results] 51 weeks on 2.4mg, full numbers, ask me anything boring

Trial Data Receipts ×7 Slow Clap ×2

51 weeks on 2.4mg, full numbers, ask me anything boring. Same spreadsheet I have been keeping since the start, nothing retrofitted.

Pulling the figures out of the title: 51 weeks and 2.4mg. All of it is written down as it happened rather than reconstructed.

Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can be formulated as a conventional tablet.

It is a non-peptide small-molecule agonist at the GLP-1 receptor. That is a substantial medicinal chemistry achievement: getting a small molecule to activate a receptor evolved for a peptide ligand.

Happy to answer the boring questions. Those are usually the ones worth asking.

2,355 up / 470 down83% upvoted31 commentsid 3f0wcd7 Jun 2025

31 comments

5 in this archive, depth 3

best — the order this archive was captured in

u/yannick_salinas250 points·1 year ago

Milligram comparisons across molecule classes are meaningless. Potency is a property of the molecule at its receptor, not of the number on the label.

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u/ravi_sandvik117 points·1 year ago

Milligram comparisons across molecule classes are meaningless.

Agreed, and it is why the oral peptide comparison keeps misleading people.

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u/flair_enthusiast139 points·1 year ago

This. The absence of food and water timing restrictions is the practical difference people will actually notice.

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u/hsa_mathOP54 points·1 year ago

phase 3 is where the comparison becomes fair

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u/emil_agyeman13 points·1 year ago·edited

Assumed the peptide purity conversations transferred and they do not. Different analytical problem entirely.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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