non-peptide: the version I wish someone had shown me in week 1
non-peptide: the version I wish someone had shown me in week 1. Posting the boring middle of the process, because the internet is full of the start and the end and nothing else. Spent an evening reading about small-molecule agonism at a peptide receptor. Genuinely interesting engineering. Daily rather than weekly…
Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can be formulated as a conventional tablet.
Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction.
Compared milligram figures across two completely different molecule classes in a comment.
Disagreeing with this bit: daily dosing is a different adherence problem, not a better one.
nothing containing this is approved anywhere and research material is not for human use
It is a non-peptide small-molecule agonist at the GLP-1 receptor. That is a substantial medicinal chemistry achievement: getting a small molecule to activate a receptor evolved for a peptide ligand.
phase 3 is where the comparison becomes fair
the boards keep comparing it to injectables at matched doses, which is meaningless