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c/orforglipron·submitted 1 year ago by u/maren_sorensen

what changed for me between month 3 and month 6

Trial Databranch of 7 comments

what changed for me between month 3 and month 6. Searched first, found three threads that contradict each other, hence the post. Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction. Went looking for independent testing on this and found essentially…

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7 comments, started 1 year ago
u/adaeze_cabrera13 points·1 year ago

Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.

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u/lina_bruun4 points·1 year ago

ATTAIN and ACHIEVE are the programmes to keep straight

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u/maren_sorensenOP2 points·1 year ago

Phase 2 or phase 3?

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[deleted]2 points·1 year ago

[deleted]

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u/aksel_kjaer1 point·1 year ago·edited

Small fix — the two programme names got swapped upthread and it changes which population the figure came from.

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u/declared_value_dv10 points·1 year ago

Milligram-for-milligram comparison with an injectable peptide is not meaningful and I should not have made it.

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u/ravi_sandvik8 points·1 year ago

Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.

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