[Question] small molecule — what am I missing here
small molecule — what am I missing here. Searched first, found three threads that contradict each other, hence the post. Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction. Went looking for independent testing on this and found essentially nothing, which…
The analytical point, which this board keeps getting wrong by importing habits from the peptide side.
For a peptide, purity is typically reported as area percent by HPLC with identity by mass spectrometry, and the impurity classes are things like deletion and oxidation products. For a small molecule the relevant impurities are synthetic intermediates, degradants and residual solvents, and identity is established differently.
So the certificate you would want looks different, the questions to ask are different, and a "purity" figure quoted here is not comparable to one quoted on the peptide boards. Anybody posting a result should say what method produced it, which is good practice everywhere and essential here.
Read both programme names carefully after mixing them up in a comment and being politely corrected.
oral semaglutide is a peptide with an absorption enhancer, this is not that
do not assume reconstitution intuitions apply, there is nothing to reconstitute
Disagree. You are comparing doses across a small molecule and a peptide, which is not a comparison of anything.