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c/orforglipron·posted 2 years ago by u/search_before_post

[Lab] GGPeps orfo — VendorInvestigate came back 99.3% against a claimed 99.0%

Speculation Well Actually ×1 Cold Box ×3

Posting this because the title is the whole finding — GGPeps orfo — VendorInvestigate came back 99.3% against a claimed 99.0% — and a number without its method is a rumour.

Hard numbers: 99.3% and 99.0%. Anything softer than that is flagged as an impression.

Nothing containing this compound is approved by any regulator, and research-use-only material is not approved for human use.

Assumed the peptide purity conversations transferred and they do not. Different analytical problem entirely.

Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.

2,854 up / 276 down91% upvoted37 commentsid 1wcguk9 Jun 2024
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37 comments

14 in this archive, depth 5

best — the order this archive was captured in

u/dario_boateng265 points·2 years ago

Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.

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u/lucia_bruun111 points·2 years ago·edited

Small fix — the two programme names got swapped upthread and it changes which population the figure came from.

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u/honest_syringe_maybe36 points·2 years ago

do not assume reconstitution intuitions apply, there is nothing to reconstitute

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u/ahmed_okafor10 points·2 years ago

Milligram comparisons across molecule classes are meaningless. Potency is a property of the molecule at its receptor, not of the number on the label.

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u/emil_agyeman4 points·2 years ago

a non-peptide agonist does not degrade the way a peptide does

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u/marit_sandvik-21 points·2 years ago

Agreed that phase 3 is where the comparison becomes fair. Everything before it is inference.

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u/search_before_postOP1 point·2 years ago

oral semaglutide is a peptide with an absorption enhancer, this is not that

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[deleted]1 point·2 years ago

[deleted]

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u/dilara_weiss1 point·2 years ago

That is a phase 2 result being quoted as though the programme had reported.

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u/tobias_molnar0 points·2 years ago

ATTAIN and ACHIEVE are the programmes to keep straight

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u/reship_roulette1 point·2 years ago·edited

This. The absence of food and water timing restrictions is the practical difference people will actually notice.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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