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c/orforglipron·submitted 1 year ago by u/freya_marchand

three years of oral GLP-1 threads, summarised so you do not have to read them

Questionbranch of 6 comments

three years of oral GLP-1 threads, summarised so you do not have to read them. Change my mind, genuinely — I have no stake in being right about this. Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.…

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6 comments, started 1 year ago
u/cloudy_vial_carol45 points·1 year ago

What analytical method was used — this is not the usual peptide assay question?

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u/marit_sandvik22 points·1 year ago·edited

What analytical method was used — this is not the usual peptide assay question?

Disagreeing with this bit: daily dosing is a different adherence problem, not a better one.

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u/viktor_laurent15 points·1 year ago

I would not assume the tolerability profile transfers exactly. Similar class effects, different exposure profile.

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u/emil_agyeman10 points·1 year ago

That is a phase 2 result being quoted as though the programme had reported.

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u/yara_boateng4 points·1 year ago

Yes — nothing containing this is approved anywhere, and the threads keep forgetting it.

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u/hamza_weiss14 points·1 year ago

Which programme and which readout are you quoting?

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