unpopular opinion: most of what gets said here about orforglipron is guesswork
unpopular opinion: most of what gets said here about orforglipron is guesswork. Making the case below, and I expect to lose some of it in the comments.
Oral semaglutide is a peptide co-formulated with an absorption enhancer and carries food and water timing requirements. A small molecule does not have that constraint, which is the practical distinction.
Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can be formulated as a conventional tablet.
It is a non-peptide small-molecule agonist at the GLP-1 receptor. That is a substantial medicinal chemistry achievement: getting a small molecule to activate a receptor evolved for a peptide ligand.
Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.
best — the order this archive was captured in
Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.
Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.
yara_boateng is right that milligram comparisons across classes tell you nothing.
Corrected a cross-class dose comparison in the title. The body is untouched.
Small fix — the two programme names got swapped upthread and it changes which population the figure came from.
no food and water restrictions is the practical difference people care about
Nothing containing this compound is approved by any regulator, and research-use-only material is not approved for human use.
Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.
Milligram comparisons across molecule classes are meaningless. Potency is a property of the molecule at its receptor, not of the number on the label.
Correcting myself: that was a phase 2 readout and I described it as phase 3.
nothing containing this is approved anywhere and research material is not for human use
- 1Daily dosing gives a very different exposure profile from a weekly…6 comments in this branch · started by u/yara_boateng