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c/orforglipron·submitted 1 months ago by u/chidi_yilmaz

anyone else notice oral GLP-1 kicking in around week 56

Speculationbranch of 10 comments

Here it is: anyone else notice oral GLP-1 kicking in around week 56. One person, one log, no control group, so read it accordingly. Why "oral" is doing two completely different jobs in the sentences people write here. Oral semaglutide is a peptide co-formulated with an absorption enhancer, which is why it comes with…

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10 comments, started 1 months ago
u/phase_two_peteMOD18 points·1 months ago

Standing reminder: unapproved compound, research material is not for human use, and no schedules for other members.

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u/chidi_yilmazOP13 points·1 months ago

Milligram-for-milligram comparison with an injectable peptide is not meaningful and I should not have made it.

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u/camila_vasquez6 points·1 months ago

oral and non-peptide is the whole engineering story

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u/zeynep_ndiaye14 points·1 months ago

Yes. Oral peptide with an absorption enhancer and oral small molecule are completely different propositions.

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u/neha_mwangi5 points·1 months ago

Right, and comparing milligrams between a small molecule and a peptide is meaningless in either direction.

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u/incretin_ivypharmacology9 points·1 months ago

Yes — nothing containing this is approved anywhere, and the threads keep forgetting it.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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